Publications

Patents

Automated Detection of Breast Cancer Lesions in Tissue
R. Bhargava, F.N. Pounder, R.K. Reddy

U.S. Patent Application No. 13/222,623
Filed on August 31, 2011.

Apparatus for controlling the propagation and transmission of light in flexible
waveguides
G.J. Tearney, R.K. Reddy

Filed in April 2014.

Optical imaging device powered by light
G.J. Tearney, R.K. Reddy

Filed in April 2015.

Actively controlled optical imaging device
G.J. Tearney, R.K. Reddy, M.J. Gora, K.K. Chu, M. Beatty
Filed in September 2015.

 

Systems and methods for an actively controlled optical imaging device
G.J. Tearney, R.K. Reddy, M.J. Gora, K.K. Chu, M. Beatty, J. Dong, E. Beaulieu-Ouellet
Filed in 2018 

Peer Reviewed Papers

Accurate histopathology from low signal-to-noise ratio spectroscopic imaging data
R.K. Reddy, R. Bhargava

Analyst, 135 , 2818-2825, 2010

[Paper]

Characterization of Tumor Progression in Engineered Tissue using Infrared Spectroscopic
Imaging

R. Kong, R.K. Reddy, R. Bhargava

Analyst, 135(7), 1569-1578, 2010

We made the cover of Analyst!
[Paper]

Dark Field Raman Microscopy
M.V. Schulmerich, R.K. Reddy, A.K. Kodali, L.J. Elgass, K. Tangella and R. Bhargava,

Anal. Chem., 82(14), 6273-6280, 2010

[Paper]

Label-free Biomedical Imaging with Mid- Infrared Spectroscopy
M.J. Walsh, R.K. Reddy, R. Bhargava,

IEEE Journal of Selected Topics in Quantum Electronics focusing on Biophotonics 2,
18(4), 1502-1513, 2012

[Paper]

Analysis of Variance components in Spectroscopic Imaging data of Tissue Microarray
J.T. Kwak, R.K. Reddy, S. Sinha, R. Bhargava

Anal. Chem., 84(12), 1063-1069, 2012

[Paper]

Discrete frequency infrared microspectroscopy and imaging with a tunable quantum cascade
laser

M.R. Kole, R.K. Reddy, M.V. Schulmerich, M.K. Gelber, R. Bhargava

Anal. Chem., 84(23), 10366-10372, 2012

[Paper]

High-definition Infrared Spectroscopic Imaging
R.K. Reddy, M.J. Walsh, M.V. Schulmerich, P. S. Carney, R. Bhargava

Appl. Spectrosc., 67(1), 93-105, 2013

William F. Meggers award winning paper!
[Paper]

Compositional prior information in computed infrared spectroscopic imaging
B.Deutsch, R.K. Reddy, D. Mayerich, R. Bhargava, P. S. Carney

Journal of the Optical Society of America A, 32(6) 1126 – 1131, 2015

[Paper]

Development of a practical spatial-spectral analysis
protocol for breast histopathology using Fourier transform infrared
spectroscopic imaging

F.N. Pounder, R.K. Reddy, R. Bhargava

Faraday discussions , 187, 43-68, 2016
[Paper]

uOCT imaging using depth of focus extension by self-imaging wavefront division in a common-path fiber optic probe
Biwei Yin, Kengyeh K. Chu, Chia-Pin Liang, Kanwarpal Singh, R.K. Reddy, and Guillermo J. Tearney

Optics express, 24(5), 5555-5564, 2016
[Paper]

Optimizing the Design of FT-IR Spectroscopic Imaging Instruments to Obtain Increased Spatial
Resolution of Chemical Species

R. Reddy, D. Mayerich, M. Walsh, M. Schulmerich, P. S. Carney, R. Bhargava,

International Symposium of Biomedical Imaging (ISBI), Barcelona, Spain, 2012

[Paper]

Rigorous Electromagnetic Model of Fourier Transform Infrared (FT-IR) Spectroscopic Imaging
Applied to Automated Histology of Prostate Tissue Specimens

R. Reddy, D. Mayerich, M. Walsh, P. S. Carney, R. Bhargava

International Conference on Optics, Lasers and Spectroscopy (ICOLS), Madrid, Spain,
2012.

[Paper]

Modeling Fourier Transform Infrared Spectroscopic Imaging of Prostate and Breast Cancer
Tissue Specimens

R.K. Reddy, B. Davis, P.S. Carney, R. Bhargava

International Symposium of Biomedical Imaging (ISBI), Chicago IL, 2011

[Paper]

Towards Better than Human Capability in Diagnosing Prostate Cancer Using Infrared
Spectroscopic Imaging
Award winning paper!
X. Llora, R. Reddy, B. Matesic, R. Bhargava

Genetic and Evolutionary Computation Conference (GECCO), London UK, 2007

[Paper]

Book Chapters

Chemometric methods for biomedical Raman spectroscopy and imaging
R.K. Reddy and R. Bhargava

Book: Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical
Fields

by M.D. Morris, P.Matousek, Springer-Verlag, Berlin Heidelberg, 2010

[Book]

Fourier transform infrared spectroscopic imaging: An emerging label-free approach for
molecular imaging

K. Yeh, R.K. Reddy and R. Bhargava

Book: Emerging Imaging Technologies in Medicine
by M. Anastasio, P.J. La Riviere, Taylor & Francis, Philadelphia, USA, 2012

[Book]

Ph.D. Thesis

Mid-Infrared Spectroscopic Imaging and Tomography
R.K. Reddy
Advisor: Dr.Rohit Bhargava

University of Illinois at Urbana Champaign, 2013.

Invited Talks

Design of high resolution FT-IR spectroscopic imaging instruments for improved breast cancer detection
R.K. Reddy, D. Mayerich, M.J. Walsh, P.S.Carney, R.Bhargava

SPIE Photonics West, San Fransisco, CA, Feb. 10th, 2015

Building mid-infrared spectroscopic imaging instruments for improved breast cancer detection
R.K. Reddy
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Feb. 3rd, 2015

High Resolution FT-IR Imaging for Improvd Breast Cancer Detection
R.K. Reddy, D. Mayerich, M.J. Walsh, P.S.Carney, R.Bhargava

Science Exchange (SciX) conference organized by Federation of Analytical Chemistry
and Spectroscopy Societies (FACSS), Reno, NV, Oct. 1st, 2014

Seeing the unseen in human tissue
R.K. Reddy, K.K. Chu, T.N.Ford, K. Singh, R.W. Carruth, D. Hyun, H. Ma, D. Mojahed, C.
Unglert, G.J. Tearney,

Science Exchange (SciX) conference organized by Federation of Analytical Chemistry
and Spectroscopy Societies (FACSS), Reno, NV, Oct. 1st, 2014

Mid-infrared Spectroscopic Imaging and Tomography
R.K. Reddy, P.S.Carney, R.Bhargava

Massachusetts General Hospital, Harvard Medical School, July 9th, 2013

Instrumentation for Infrared Spectroscopic Imaging
R.K. Reddy, R.Bhargava

Lam Research, Fremont, California, October 23rd, 2012

Vibrational Spectroscopy
R.K. Reddy, Thomas van Dijk, R.Bhargava

Roger Adams Laboratory, University of Illinois at Urbana Champaign, Jan 31st, 2012

Fourier Transform Infrared (FT-IR) Spectroscopic Imaging of Human Tissue Specimens
R.K. Reddy, D. Mayerich, M.J. Walsh, M.V. Schulmerich, P.S.Carney, R.Bhargava

Beckman Graduate Seminar, Beckman Institute for Advanced Science and Technology,
Urbana IL, Nov 2, 2010

Conference Presentations

Tethered Capsule Endomicroscopy for Barretts Esophagus Screening
R.K. Reddy, M.J. Gora, R. Carruth, T.N. Ford, J. Dong, G.J. Tearney,

Science Exchange (SciX) conference organized by Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), Providence, RI, Oct. 1st, 2015

Functional micron-resolution imaging with micro-optical coherence tomography
R.K. Reddy, K.K. Chu, T.N.Ford, K. Singh, R.W. Carruth, D. Hyun, H. Ma, D. Mojahed, C. Unglert, G.J. Tearney

Science Exchange (SciX) conference organized by Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) , Reno,
NV, Oct. 2nd, 2014

Improved Breast Cancer Detetion from High-Resolution Fourier Transform Infrared (FTIR)
Spectroscopic Imaging

R.K. Reddy, D. Mayerich, M.J. Walsh, M.V. Schulmerich, R. Bhargava

Science Exchange (SciX) conference organized by Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) ,
Milwakee, WI, Oct. 3rd, 2013

Classification of Prostate and Breast Tissue Data from High-Resolution Fourier Transform
Infrared (FTIR) Spectroscopic Imaging

R.K. Reddy, D. Mayerich, M.J. Walsh, M.V. Schulmerich, R. Bhargava,

Science Exchange (SciX) conference organized by Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) , Kansas
City, MO, Oct. 1st, 2012

High resolution FT-IR spectroscopic imaging instruments for cancer detection
R.K. Reddy, M.J. Walsh, M. Schulmerich, P.S. Carney, R. Bhargava

(Poster) Univ. of Illinois at Urbana Champaign Community at Illinois Symposium, Chicago, April 5th, 2012

Rigorous Electromagnetic Model of Fourier Transform Infrared (FT-IR) Spectroscopic Imaging
Applied to Automated Histology of Prostate Tissue Specimens

R.K. Reddy, D. Mayerich, M. Walsh, P. S. Carney, R. Bhargava

International Conference on Optics, Lasers and Spectroscopy (ICOLS), Madrid, Spain, March 28th, 2012

Design of high resolution FT-IR spectroscopic imaging instruments for cancer detection
R.K. Reddy, M.J. Walsh, M. Schulmerich, P.S. Carney, R. Bhargava

(Poster) Univ. of Illinois at Chicago Cancer Center Research Forum, Chicago, March 6th, 2012

High Definition Fourier Transform Infrared (FT-IR) Spectroscopic Imaging
R. Reddy, D. Mayerich, M. Walsh, M. Schulmerich, P.S. Carney, R. Bhargava

Midwest ACS meeting, Oct. 19th, 2011

Overcoming Spectral Distortions in Fourier Transform Infrared (FT-IR) Spectroscopic
Imaging

R.K. Reddy, P.S. Carney, R. Bhargava,

Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) , Reno, NV, Oct. 2nd, 2011

Theory of resolution and image quality in mid-IR imaging
R. Bhargava, T. van Dijk, R.K. Reddy, P.S. Carney

Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) 2011, Reno, October 3rd, 2011.

High-Definition FT-IR Spectroscopic Imaging
R.K. Reddy, R. Bhargava

Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) , Reno, NV, Oct. 4th, 2011

High Definition Fourier Transform Infrared (FT-IR) Spectroscopic Imaging (Award Winning Poster!)

R.K. Reddy, M.J. Walsh, M. Schulmerich, P.S. Carney, R. Bhargava

(Poster) Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) 2011, Reno, NV, Oct. 4th, 2011

Fourier-Transform Infrared Spectroscopic Imaging for Histopathology
R.K. Reddy, R.Bhargava

(Poster) BioSensing and BioActuation Summer Institute 2011, National Taiwan University, Taiwan, July 22nd, 2011

Modeling Fourier transform infrared spectroscopic imaging of Prostate and breast cancer
tissue specimens

R.K. Reddy, B.J. Davis, P.S. Carney, R. Bhargava

IEEE International Symposium on Biomedical Imaging (ISBI), Chicago, March 30th, 2011

Enhanced Models for Fourier Transform Infrared (FT-IR) Spectroscopic Imaging of Human Tissue
Specimens
(Award Winning Poster!)

R.K. Reddy, B.J. Davis, P.S. Carney, R. Bhargava

Federation of Analytical Chemistry and Spectroscopy Societies FACSS ), Rayleigh, NC, Oct. 4th, 2010

Modeling, Data Visualization and Histopathology using Fourier Transform Infrared (FT-IR) 
Spectroscopic Imaging of Human Tissue Specimens
(Award Winning Poster!)

R.K. Reddy, F.N. Pounder, R. Bhargava

(Poster), Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), Louisville, KY, Oct. 19th, 2009

Modeling, Data Visualization and Histopathology using Fourier Transform Infrared (FT-IR)
Spectroscopic Imaging of Human Tissue Specimens

R.K. Reddy, R. Bhargava

Biomedical Engineering Society Conference (BMES), Pittsburgh, PA, Oct. 8th, 2009

Fourier-Transform Infrared Spectroscopic Imaging
R.K. Reddy, R.Bhargava

(Poster) NanoBiophotonics Summer School 2009, Urbana IL, June 4th, 2009

Advances in Automated Histopathology using Fourier Transform Infrared (FT-IR) Spectroscopic
Imaging

R.K. Reddy, R. Bhargava

(Poster) Univ. of Michigan at Ann Arbor, Midwestern Biomedical Engineering Conference, April 3rd, 2009

Robustness of Tissue Classification using FT-IR Imaging
R.K. Reddy, R. Bhargava

Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) , Reno, NV, Sept. 30th, 2008

Enhancing the tissue segmentation capability of fast infrared spectroscopic imaging via
chemometric methods,

R. Bhargava, F.N. Pounder, R.K. Reddy, X. Llora

Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) , Reno, NV, Sept. 30th, 2008

Advances in Automated Histopathology using Fourier Transform Infrared (FT-IR) Spectroscopic
Imaging

R.K. Reddy, R. Bhargava

(Poster) Biomedical Engineering Society Conference (BMES), St.Louis, MO, Oct 3rd, 2008

Computational Methods for Enhancing Infrared Spectroscopic Imaging (Award Winning Poster!)

R. Reddy, R.Bhargava

Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) , Memphis TN, Oct 14th, 2007

Masters Thesis

3D Warped Discrete Cosine Transform and its application in Image Compression
R.Reddy, K.M.M.Prabhu

Indian Institute of Technology Madras, Chennai, India, July 2006.

Other Publications

Denoising and deblurring of Fourier-trasform infrared spectroscopic imaging
T.H. Nguyen, R.K. Reddy, M. J. Walsh, M. Schulmerich, G. Popescu, M.N. Do, R. Bhargava

Society of Photo-Optical Instrumentation Engineers (SPIE) Photonics West, Paper No. 8296-20, 2012

Re-imagining FT-IR imaging and applications with new theory and instruments
R. Bhargava, P.S. Carney, R.K. Reddy
SciX, Kansas City, October 2012

Development of highly sensitive and specific vibrational spectroscopic imaging guided by new theory
R. Bhargava, A.K. Kodali, X. Llora, R.K. Reddy, M.J. Walsh, P.S. Carney

EAS 2011, Somerset, NJ, November 2011

Validating the cancer diagnosis potential of mid-infrared spectroscopic imaging
F.N. Pounder, R.K. Reddy, M. Walsh and R. Bhargava

Society of Photo-Optical Instrumentation Engineers (SPIE 2009) Photonics West, Paper No. 7186-14, 2009

Practical protocols for ultrafast histopathology by Fourier transform infrared imaging
F.N. Keith, R.K. Reddy, and R. Bhargava

Society of Photo-Optical Instrumentation Engineers (SPIE) Photonics West, Paper No. 6853A-5, 2008